BIOPHARM SYSTEMS

Paul Mueller Company Get to Know Mueller® PyroPure® Products Since our inception in 1940, Paul Mueller Company has evolved from a small-scale fabricator into a global process solution provider with one million square feet of manufacturing space. Mueller® offers a full range of tanks from shop-fabricated alloy vessels up through 20 feet in diameter to field-fabricated vessels up through 2,000,000 gallons; furthermore, Mueller offers integrated systems, modular fabrication, field construction, plant maintenance and repair, and complete turnkey project execution. Our facility is uniquely qualified...

Our Philosophy is Simple: We are committed to meeting and exceeding our customers’ expectations of value by providing high quality equipment, excellent service, and complete process solutions.

Paul Mueller Company PyroPure Pure Steam Generators The Mueller PyroPure P7000 Series Advantage Mueller PyroPure pure steam generators are capable of producing pyrogen-free pure steam that, when condensed, meets all U.S. Pharmacopoeia (USP) requirements for use in autoclaves, critical area humidification, and routine steamin-place (SIP) sterilization. Feedwater enters the system and flows through two level control valves and then into the tube side of the blowdown cooler. In the blowdown cooler, heat is transferred between the feedwater on the tube side and the blowdown exiting the system through...

System Components Evaporator. The natural circulation design of the PyroPure double-tubesheet evaporator ensures maximum surface wetting, eliminating the hot, dry areas that lead to the stress cracking associated with other designs. The tube bundle creates a large heat transfer surface that vaporizes feedwater almost instantly to allow the unit to respond to large loads. Mueller PyroPure pure steam generators have a fully drainable external evaporator, eliminating the need for the excess headroom required for evaporator removal with other designs. All surfaces that come into contact with pure...

Optional equipment indicated: • Degasser • Pure steam condensate sampling system with analyzer • Feedwater analyzer Pure steam out Sample port Paul Mueller Company The Mueller PyroPure P7000 Series Advant

Paul Mueller Company Pressure and Temperature Charts PyroPure Pure Steam Generator Capacity Curves 1. Select the chart(s) with pure steam capacities closest to the one you need. 2. Locate your supply steam pressure on the vertical axis. 3. Follow that line across to the point where it intersects with the curve representing your required pure steam pressure. 4. Drop down from this point to the horizontal axis to determine the model’s pure steam capacity. 5. Select the model which most closely fits your capacity needs given your pressure requirements. Note: Capacities shown are approximate and...

Input Steam Supply Pressure (bar) Input Steam Supply Pressure (bar) Pure Steam Output Pressure Curve Pure Steam Capacity lb/hr (kg/hr) Input Steam Supply Pressure (bar) Pure Steam Output Pressure Curve Pure Steam Capacity lb/hr (kg/hr) Pure Steam Output Pressure Curve Input Steam Supply Pressure (bar) Pure Steam Capacity lb/hr (kg/hr) Input Steam Supply Pressure (bar) Pure Steam Output Pressure Curve Pure Steam Capacity lb/hr (kg/hr) Pure Steam Output Pressure Curve

Paul Mueller Company PyroPure Pure Steam Condensing System The Mueller PyroPure P4000 Series Advantage The Mueller PyroPure pure steam condensing systems are designed for use by companies in the pharmaceutical and biotechnological industries who want to use their pure steam generating systems for the production of WFI quality distillate as well as WFI quality pure steam. When used with a Mueller PyroPure pure steam generator or when fed WFI quality pure steam from another source, the water produced will be pyrogen free and will meet or exceed the latest specifications of the USP for water-for-injection...

System Components Condenser. Mueller PyroPure condensers have a double-tubesheet design, providing users with efficient heat exchange while ensuring pure vapor and distillate never come into contact with feedwater and coolant. To facilitate maintenance, all PyroPure condensers are mounted at an angle to allow full drainage of the pure distillate through the distillate outlet port installed at the vessel’s lowest point. The condenser is designed to allow the removal of the U-tube bundle for easier inspection of critical pure distillate contact surfaces. Controls. An Allen Bradley PLC with an Allen...

Paul Mueller Company PyroPure Single-Effect Stills The Efficient Mueller PyroPure Single-Effect Still Mueller PyroPure single-effect stills (SES) are a smaller distillation units designed to meet the needs and budgets of growing organizations interested in developing new products. The SES is capable of producing up to 50 gallons of WFI per hour. The SES is manufactured according to FDA current Good Manufacturing Practices (cGMPs). It features a pharmaceutical vent filter, double-tube-sheet condenser, and evaporator, including stainless steel seamless evaporator and condenser tubing, and stainless...

’ Plant Steam 60 psig (4.! barg) dry and saturated. 2 Coolant water at 32°F to 80°F (0°C to 26°C) at 40 psig (2.8 barg). (Flow rates based upon a distillate outlet temperature of i90°F [88°C] and cooling water inlet temperature of 60°F [i6°C]). 3Other electrical services must be specified at time of order.

Paul Mueller Company PyroPure Multiple-Effect Stills The Mueller PyroPure P6000 Series is Built to Last Mueller PyroPure multiple-effect stills (MES) are the simplest, most reliable means of producing pyrogen-free waterfor-injection (WFI) that meets all U.S. Pharmacopoeia requirements. The MES is designed with efficiency in mind. Because the system recovers the latent heat of vaporization occurring within its own process to heat feedwater and uses feedwater as its primary source of cooling, the MES is an energy and money-saving model of ingenuity. Due to the absence of moving parts, the PyroPure...