Overview

This document presents Glycoline, a nutritional supplement designed to improve dairy cow performance by reducing metabolic stress and stimulating feed intake. It focuses on managing metabolic stress through a synergistic blend of four glucogenic agents that serve as glucose precursors and neoglucogenesis catalysts.

Key Components and Their Roles

• Monopropylene glycol, Glycerol, Sorbitol, Propionate: These four glucogenic agents work synergistically to increase blood glucose levels and reduce ketone bodies, supporting energy metabolism.
• Cobalt (Vitamin B12 precursor): Essential for energy metabolism and synthesis of methionine and choline.
• Niacin (Vitamin PP): Inhibits lipolysis, reduces circulating non-esterified fatty acids (NEFA), and stimulates glucogenic metabolism.

Physiological Importance of Glucose

Glucose is critical for:

• Milk production, as it is the sole precursor for lactose synthesis in the udder.
• Immune system efficiency, with activated leucocytes consuming up to 2 kg of glucose daily.
• Reproductive health, necessary for follicle recruitment, growth, and rapid uterine involution.

Systemic inflammation around calving and various stressors increase glucose consumption, making supplementation vital.

Metabolic Stress and Ketosis

Subclinical ketosis remains a significant issue during the transition period, calving, and under stress conditions such as heat, social, transportation, and weaning stress. Key points include:

• 43% of cows between 3 to 16 days in milk (DIM) test positive for beta-hydroxybutyrate (BHBA), indicating ketosis.
• Ketosis leads to increased risk of left displaced abomasum (LDA), higher culling rates, and reduced milk yield.
• Economic cost per case of ketosis is approximately €289, including losses from reproduction, milk production, diagnosis, therapeutics, and labor.

Clinical and Field Trial Results

• Feeding Glycoline (300 g/day from 20 days prepartum to 30 days postpartum) increased blood glucose and decreased BHBA levels, improving milk production and metabolic health.
• Field trials under heat stress conditions (THI 75-85) showed Glycoline supplementation increased milk yield by an average of +2.34 kg/cow at 50 DIM and raised plasma glucose by +5.1 mg/dL while reducing BHBA by -0.4 mmol/L.
• Data from multiple countries (Vietnam, Spain, China, France, Iran, Saudi Arabia, Serbia) confirm consistent positive effects on milk yield and metabolic parameters.

Administration and Dosage Recommendations

Glycoline is available in liquid, powder, and pellet forms with flexible dosing options:

• Dairy cows: 150-200 mL/day when THI > 70, administered via top feeding on TMR, mixed in TMR, automatic feeders, or drinking water dosing pumps.
• Goats and ewes: 30 mL or 50 g one month before kidding; 50 mL or 70 g one month after kidding to prevent pregnancy toxemia and ketosis.
• Beef cattle: 40 mL per 100 kg live weight at arrival and before slaughter.
• Ketosis treatment: 400 mL/cow/day for 5 days; drench solution option at 500 mL/cow.

Product Variants and Additional Solutions

• Glycoline Sweet: Enhanced palatability for dairy cows.
• Glycoline Green: Contains monopropylene glycol of vegetal origin.
• Natoline: Energy booster without propylene glycol.
• Glycanion: Prevents hypocalcemia and energy deficit during close-up period.

Summary of Benefits

• Improves metabolic health by increasing blood glucose and reducing ketone bodies.
• Enhances milk production and reproductive performance.
• Mitigates effects of heat and other stressors on dairy cows.
• Supports immune function and reduces metabolic disorders such as ketosis.

References and Sources

Data and research cited include studies from the University of Aarhus, McArt et al. (2012, 2015), Kvidera et al. (2017), and various international field trials conducted between 2005 and 2018.

Contact Information

Vitalac, France - Brittany
Tel: +33 (0)2 96 21 52 78
Website: www.vitalac.eu